Is microalbuminuria progressive?

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Is microalbuminuria progressive?

In 1990, 81 children and adolescents with insulin dependent diabetes were studied for early signs of diabetic nephropathy. Nine patients were identified as having microalbuminuria (incipient nephropathy). These subjects were re-examined three years later. In five of these cases, the second examination revealed normal albumin excretion; in three of the four cases in whom microalbuminuria persist...

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How heterogeneous is microalbuminuria in diabetes mellitus? The case for 'benign' and 'malignant' microalbuminuria.

of both hypertension [11] and coronary heart disease The concept of microalbuminuria was introduced more [12] among the non-diabetic parents of patients with than 30 years ago when it became possible to measure nephropathy. With regard to NIDDM, it has been concentrations of urinary albumin below the level of reported that non-diabetic relatives of NIDDM detection of a urinary protein dipstick ...

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Microalbuminuria and the risk for early progressive renal function decline in type 1 diabetes.

This study aimed to establish the time of initiation and the determinants of renal function decline in type 1 diabetes. Until now, such decline has been assumed to be a late-occurring event associated with proteinuria. A total of 267 patients with normoalbuminuria and 301 patients with microalbuminuria were followed for 8 to 12 yr. Linear trends (slopes) in GFR were estimated by serial measurem...

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Early Progressive Renal Decline Precedes the Onset of Microalbuminuria and Its Progression to Macroalbuminuria

OBJECTIVE Progressive decrease in the glomerular filtration rate (GFR), or renal decline, in type 1 diabetes (T1D) is observed in patients with macroalbuminuria. However, it is unknown whether this decline begins during microalbuminuria (MA) or normoalbuminuria (NA). RESEARCH DESIGN AND METHODS The study group (second Joslin Kidney Study) comprises patients with T1D and NA (n = 286) or MA (n = ...

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North Carolina's dominant progressive foveal dystrophy: how progressive is it?

We studied 34 family members at risk of having dominant progressive foveal dystrophy of Lefler, Wadsworth, and Sidbury (also called North Carolina macular dystrophy) and found 17 to be affected. Fifteen of these affected subjects were observed over at least a 10-year period for evidence of progressive macular degeneration. Only one subject showed objective evidence of progressive deterioration ...

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ژورنال

عنوان ژورنال: Archives of Disease in Childhood

سال: 1996

ISSN: 0003-9888,1468-2044

DOI: 10.1136/adc.75.3.266-a